Intermittent hypoxia impairs uterine artery function in pregnant mice
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Metoprolol impairs resistance artery function in mice.
Acute β-blockade with metoprolol has been associated with increased mortality by undefined mechanisms. Since metoprolol is a relatively high affinity blocker of β(2)-adrenoreceptors, we hypothesized that some of the increased mortality associated with its use may be due to its abrogation of β(2)-adrenoreceptor-mediated vasodilation of microvessels in different vascular beds. Cardiac output (CO;...
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Angiotensin-converting enzyme 2 (ACE2) knockout is associated with reduced fetal weight at late gestation; however, whether uteroplacental vascular and/or hemodynamic disturbances underlie this growth-restricted phenotype is unknown. Uterine artery reactivity and flow velocities, umbilical flow velocities, trophoblast invasion, and placental hypoxia were determined in ACE2 knockout (KO) and C57...
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We recently reported that adrenomedullary chromaffin cells (AMC) from neonatal rats treated with intermittent hypoxia (IH) exhibit enhanced catecholamine secretion by hypoxia (Souvannakitti D, Kumar GK, Fox A, Prabhakar NR. J Neurophysiol 101: 2837-2846, 2009). In the present study, we examined whether neonatal IH also facilitate AMC responses to nicotine, a potent stimulus to chromaffin cells....
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متن کاملUterine Artery Dysfunction in Pregnant ACE2 Knockout Mice is Associated with Placental
Uterine Artery Dysfunction in Pregnant ACE2 Knockout Mice is Associated with Placental 1 Hypoxia and Reduced Umbilical Blood Flow Velocity 2 3 Liliya M. Yamaleyeva, Victor M. Pulgar, Sarah H. Lindsey, Larissa Yamane, Jasmina 4 Varagic, Carolynne McGee, Mauro daSilva, Paula Lopes Bonfa, Susan B. Gurley, K. 5 Bridget Brosnihan 6 7 The Hypertension & Vascular Research Center, Department of Obstetr...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2019
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jp277775